5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
CAS: 757978-33-9
Molecular Formula: C8H5BrN2O
5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde - Names and Identifiers
5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde - Physico-chemical Properties
| Molecular Formula | C8H5BrN2O |
| Molar Mass | 225.04 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Irritant |
| MDL | MFCD09755969 |
5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde - Introduction
5-Bromo-1H-Pyrrolo [2,3-b]pyridine-3-carbaldehyde is an organic compound with the following properties:
1. Appearance: colorless or light yellow solid.
2. molecular formula: C9H5BrN2O.
3. Molecular weight: 234.05g/mol.
4. Melting point: about 130-133 degrees Celsius.
5. Solubility: Soluble in common organic solvents, such as methanol and dichloromethane.
Its main uses include:
1. drug synthesis: can be used as intermediates for the synthesis of various drugs and bioactive compounds.
2. organic synthesis: can be used to construct and modify organic molecules, such as the synthesis of heterocyclic compounds and heterocyclic parallel compounds.
3. research purposes: can be used as a chemical reagent, such as in the catalytic reaction or catalytic hydrogenation reaction as a catalyst.
In terms of preparation method, 5-Bromo-1H-yrrolo [2,3-b]pyridine-3-carbaldehyde can be synthesized by the following steps:
1. First, 3-cyano-5-bromo-1H-pyrrolo [2,3-b] pyridine is generated by reacting 3-cyanopyridine as a starting material with bromoacetyl.
2. Subsequently, 3-cyano-5-bromo-1H-pyrrolo [2,3-b] pyridine was converted into 3-hydroxy-5-bromo-1H-pyrrolo [2,3-b] pyridine by a hydrolysis reaction.
3. Finally, 3-hydroxy-5-bromo-1H-pyrrolo [2,3-b]pyridine was converted to 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde by hydroxymethylation.
Regarding safety information, due to the lack of specific experimental conditions and operating details, detailed safety information of the compound cannot be provided. Generally speaking, when handling chemicals, you should follow laboratory safety procedures and pay attention to protective measures, such as wearing appropriate protective glasses, gloves and laboratory clothes, ensuring that you operate in a well-ventilated environment, avoiding inhalation, intake and skin contact. The compound should also be stored and disposed of appropriately on a case-by-case basis.
1. Appearance: colorless or light yellow solid.
2. molecular formula: C9H5BrN2O.
3. Molecular weight: 234.05g/mol.
4. Melting point: about 130-133 degrees Celsius.
5. Solubility: Soluble in common organic solvents, such as methanol and dichloromethane.
Its main uses include:
1. drug synthesis: can be used as intermediates for the synthesis of various drugs and bioactive compounds.
2. organic synthesis: can be used to construct and modify organic molecules, such as the synthesis of heterocyclic compounds and heterocyclic parallel compounds.
3. research purposes: can be used as a chemical reagent, such as in the catalytic reaction or catalytic hydrogenation reaction as a catalyst.
In terms of preparation method, 5-Bromo-1H-yrrolo [2,3-b]pyridine-3-carbaldehyde can be synthesized by the following steps:
1. First, 3-cyano-5-bromo-1H-pyrrolo [2,3-b] pyridine is generated by reacting 3-cyanopyridine as a starting material with bromoacetyl.
2. Subsequently, 3-cyano-5-bromo-1H-pyrrolo [2,3-b] pyridine was converted into 3-hydroxy-5-bromo-1H-pyrrolo [2,3-b] pyridine by a hydrolysis reaction.
3. Finally, 3-hydroxy-5-bromo-1H-pyrrolo [2,3-b]pyridine was converted to 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde by hydroxymethylation.
Regarding safety information, due to the lack of specific experimental conditions and operating details, detailed safety information of the compound cannot be provided. Generally speaking, when handling chemicals, you should follow laboratory safety procedures and pay attention to protective measures, such as wearing appropriate protective glasses, gloves and laboratory clothes, ensuring that you operate in a well-ventilated environment, avoiding inhalation, intake and skin contact. The compound should also be stored and disposed of appropriately on a case-by-case basis.
Last Update：2024-04-09 21:50:46
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